During the Qing dynasty, Zhang Boxing (張伯行) established the Ziyang College (紫陽書院) inside the Suzhou Prefecture School.

He also invited sinology masters Wang Guowei and Luo Zhenyu to join the faculty of the school.

In a 2016 ranking of Chinese high schools that send students to study in American universities, Suzhou High School ranked number 39 in mainland China in terms of the number of students entering top American universities.

[10] The same year, Fan Zhongyan donated a house, and began the construction of quasi-government school after the approval of the Emperor Ren Zong.

During the Qing dynasty, Zhang Boxing (张伯行) established the Ziyang College (紫阳书院) in the Suzhou Prefecture School.

[15] In 1902, Ziyang College was renamed to Xiaoshiguan (校士馆, literally meaning a place for school scholars).

He invited sinology great masters Luo Zhenyu and Wang Guowei to the school, serving as principal and teacher respectively.

After Wang resigned in 1931,[22] Jiangsu Province Department of Education let geographer Hu Huanyong at National Central University to take this position temporarily.

In the 1st Jiangsu Provincial High School Graduate Examination held in 1933, SHS students attracted nationwide attention by having 24 of them ranked in Top 100 in the province.

The students and faculty members had to change their campus again when Japanese occupied the whole Sunan (Southern Jiangsu) region.

[27] In October 1945, Suzhou High School finally returned to its original campus after the surrender of Japan.

The symbol of Suzhou High School is the Science Building facing the main gate near Renmin Road.