After Chichester College, she attended drama school at the Academy of Live and Recorded Arts[4] in London, where she first performed stand-up.

[12] After a year and a half hiatus due to the COVID-19 pandemic, Ruffell resumed the Dance Like Everyone's Watching tour in autumn 2021.

In 2017, Ruffell and her friend Tom Allen performed across the UK on a double-bill tour titled Hit the Road!

[17] Ruffell appeared with five other British female celebrities in the 2021 BBC2 documentary Womanhood, with the guests discussing the evolving status of women over the past 50 years.

[18] Also in 2021, Ruffell was a presenter on the first two episodes of a female-led satirical news show on Comedy Central titled Yesterday, Today & The Day Before.

[24] In 2023, Ruffell became the co-host of the podcast, Big Kick Energy, with fellow comedian Maisie Adam.

[31] Ruffell was nominated for the Leicester Mercury Comedian of the Year 2011, making it to the finals,[15] and was awarded second place in the Latitude Festival New Act Competition 2011.

[14] A sitcom pilot collaboration with playwright Jon Brittain in 2012 led to a nomination for the BAFTA Rocliffe New Writing Award.