Nonso Anozie, Christian Convery, Adeel Akhtar, Stefania LaVie Owen, Dania Ramirez, Aliza Vellani, Will Forte, Neil Sandilands, Marlon Williams, Amy Seimetz, Rosalind Chao, Kelly Marie Tran, and Cara Gee star while James Brolin provides the narration.

[5] The main story follows Gus (played by Convery), a naïve 10-year-old deer hybrid, who sets out to find his mother after his father's death.

Ten years ago occurred "The Great Crumble", the collapse of society due to a viral pandemic of a disease known as the Sick (or the H5G9 virus), wiping out most of the world's human population.

[12] On May 12, 2020, Christian Convery, Nonso Anozie, Adeel Akhtar, and Will Forte were cast in starring roles with James Brolin set to narrate the series.

The website's critics consensus reads, "Emotionally engaging, superbly acted, and incredibly entertaining, Sweet Tooth will satisfy fantasy fans of all ages.

[28] Reviewing the series for Rolling Stone, Alan Sepinwall gave a rating of 3.5/5 and said, "Whether Gus and friends are having scary adventures or fun ones, those parts of Sweet Tooth are full of life, and as exciting or tense as needed.

It is either warmly eccentric or hysterically crazy, perfect entertainment or a horrifying attempt to parlay the pandemic into a commercially palatable mashup.

"[30] Daniel D'Addario of Variety also gave the series a positive review, writing "Throughout, the show is made with a surprising degree of curiosity about what changes in society would look like across varying sorts of communities, and with a capacious imagination to boot.

"[31] Brian Tallerico of RogerEbert.com wrote in his review that "Netflix's brilliant "Sweet Tooth" may not be a direct commentary on what the world has been through in the last year, but the presence of that real-world echo is undeniable.

It's a show about a devastating virus that leads people to distrust one another, go into hiding, allow their fear to drive their decisions, and ultimately form unexpected bonds.

It's intense, riveting storytelling that recalls the spirit of Amblin almost more than the nostalgia warehouse that is "Stranger Things," the king of Netflix Originals.

Sweet Tooth combines an examination of that inequality with the morals of other excellent post-apocalyptic stories, like 28 Days Later and Mad Max: Fury Road, which argue that survival is not enough to keep people functioning.

Sweet Tooth's subject matter might seem too bleak for the current era, but its timeliness also empowers the show's message of hope and shared strength.

The website's critics consensus states, "More mature but still suitable for younger viewers, Sweet Tooth's sophomore season makes post-apocalyptic survival fun for the whole family.

The website's critics consensus reads, "Closing out before it grows too long in the tooth, this richly imagined family series remains engrossing to the very end.