The men's 100 metre butterfly competition at the 2022 Mediterranean Games was held on 5 July 2022 at the Aquatic Center of the Olympic Complex in Bir El Djir.

[1] Prior to this competition, the existing world and Mediterranean Games records were as follows: The following new records were set during this competition.

The heats were started at 10:00.

[2] The final was held at 18:00.

[3]