The men's 50 metre butterfly competition at the 2022 Mediterranean Games was held on 1 July 2022 at the Aquatic Center of the Olympic Complex in Bir El Djir.

Prior to this competition, the existing world and Mediterranean Games records were as follows: The following records were established during the competition: The heats were started at 10:10.

[1] The final was held at 18:04.

[2]