Sibylle of Saxony (2 May 1515 in Freiberg – 18 July 1592 in Buxtehude) was a Saxon princess of the Albertine line of House of Wettin and by marriage Duchess of Saxe-Lauenburg.

This relationship turned out to be important for Sibylle's brother Maurice during the Schmalkaldic War.

The marriage proved unhappy and Francis accused Sibylle of vindictive and unloving acts.

In 1552, Sibylle asked her brother Maurice to financially assist her husband, so he could redeem some goods and villages from Lübeck.

[2] In 1588, the Duchess played a prominent role in the affair of her son Maurice, who lived in Buxtehude in the Altkloster [nds] Abbot's House since 1585/86, with Adam von Tschammer's wife Gisela against whom she initiated a trial of witchcraft.