After leaving Yew Tree Secondary Modern School, Wythenshawe, and working as an interior decorator, Little began his performing career as a singer and guitarist in Manchester pubs before teaming up with Large.

Other TV appearances in recent years include Ant and Dec's Saturday Night Takeaway, Britain's Great Double Acts, Double Acts at Christmas, Bradley Walsh's When Dummies Ruled The World.

In January 2019 Syd and Eddie appeared as headline guests for the Slapstick comedy festival speaking about their lives and career to a sold out audience at a Bristol theatre.

In 2022, Little appeared on Sky UK's Celebrity Auction House (S2, E5) and raised over £1,000 for his "new pet project".

He auctioned several personal items, including his own electric guitar, which he signed back and front.