[2] She has previously played for the New York Liberty, San Antonio Stars, Minnesota Lynx, Chicago Sky, and the Las Vegas Aces in the WNBA, and overseas in Poland and Israel.

[7] Recruited by future Naismith Memorial Basketball Hall of Fame coach Gary Blair,[6] Colson committed to Texas A&M University over offers from LSU and Oklahoma.

[10] Colson spent her freshman season as a reserve on the first Texas A&M team to reach the Elite Eight in program history, backing up point guard A'Quonesia Franklin.

Colson successfully rehabilitated the injury, returning to play eight minutes in the Aggies' season opener on November 14, 2008, against Mercer, 128 days after undergoing surgery to repair the torn ligament.

[16] In the national semifinals, with 3.3 seconds left in the game, Colson dished the game-winning assist to Tyra White to defeat first-seeded Stanford 63–62 to advance to the finals against Notre Dame.

[22] After being cut by the Liberty, Colson spent the 2011–12 and 2012–13 seasons playing overseas in Poland for Lider Pruszkow in the Polska Liga Koszykówki Kobiet.

The next year, Colson scored in double figures in 11 of the 21 games she played in the 2012–13 season, helping Lider Pruskow advance to the Polish Cup Semifinals.

[23] After several seasons out of the WNBA, Colson signed a training camp contract with the San Antonio Stars on May 15, 2015, shortly after joining Rice University as an assistant coach.

[27] In her Lynx debut on August 14, 2018, Colson tallied three points, two rebounds, two assists and a block in five-plus minutes of play against the Chicago Sky.

[36] During a single-elimination game in the second round of the 2019 WNBA playoffs against the Chicago Sky, Colson's defense played a key role in what became known as the "Hamby Heave".

[40] During the 2021-22 WNBA offseason, Colson played in Las Vegas with Athletes Unlimited during the development league's inaugural season, serving on player executive committee.

[46] In Game 4 of the 2023 WNBA Finals against the New York Liberty, after injuries sidelined starters Chelsea Gray and Kiah Stokes, Colson's defense played a key role in the Aces' 70–69 victory.

[49][50] After playing overseas in Poland, Colson returned to her alma mater Texas A&M in January 2014 as a graduate assistant, reuniting with her college coach Gary Blair.

[63] Colson is close friends with former Aces teammate Theresa Plaisance, with whom she starred in The Syd & TP Show, an unscripted buddy comedy series co-produced by Ryan Reynolds's Maximum Effort and Fubo.

[64] In October 2024, Colson appeared in a TikTok ad campaign for Togethxr and Aflac alongside Aces' teammate, Kate Martin.