He holds a Master of Science degree in State, Society and Development from the University of London, and has a PhD specializing in Political Economy of Automotive Manufacturing.
[1] [3] In 1976, with the spread of the Soweto uprising into other areas of the country, Mufamadi became a member of Zoutpansberg Students Organisation, which led to the boycotts in Venda during October 1977.
In 1980, Mufamadi worked as a private teacher at Lamula Secondary School, Soweto, where he assisted members of the Congress of South African Students with political activities.
In 1981, he left the teaching profession to work as a messenger for a firm of attorneys and subsequently joined the General and Allied Workers Union and participated in the 16 June stay-away that year.
In 1983, he attended the launch of the United Democratic Front in Cape Town, and was later elected Transvaal publicity secretary of the organisation, a position he held until 1990.
In 1985, when the state of emergency was declared, Mufamadi operated underground to avoid detention, resurfacing to help organise and attend the December 1985 launch of the Congress of South African Trade Unions in Durban, where he was elected Assistant General Secretary at its inaugural rally.
After the 1994 general election, Mufamadi was appointed as Minister of Safety and Security in the Government of National Unity until 1999, after having served on the sub-council on law and order of the Transitional Executive Council.