In the spring of 1839, Byrne and Malone left from Kingstown for Liverpool where on 10 April they sailed to Philadelphia, arriving on 12 May 1839.
The following year the seminary moved to Rose Hill in Fordham, where Malone continued his studies.
Shortly afterward, Malone was visiting Father Joseph P. Burke, pastor of St. Peter's Church in Poughkeepsie, who asked him to attend a small mission a few miles away.
He befriended the Irish born Architect Patrick Keely and together they were responsible for a number of church buildings.
[2] A man noted for his tolerance he was friendly with clerics from other Christian churches and local rabbis.