Sylvester Zobieski Earle (August 7, 1822 – March 1, 1888) was a physician and political figure in New Brunswick, Canada.

He was born in Kingston, New Brunswick, the son of Sylvester Zobieski Earle and Maria Hughson, and studied medicine at the University of the City of New York.

In 1845, Earle returned to New Brunswick and joined his father in practice at Hampton.

He also served as commissioned surgeon in the local militia with the 62nd Saint John Fusiliers, serving with the Fenian Raids in 1866.

Earle helped lead the reconstruction efforts following the great fire in Saint John in June 1877.