[5] She hosts several events at TMF, such as presenting the annual TMF-awards, and conducting interviews with international artists such as Britney Spears and Kylie Minogue.

After being elected the Netherlands' Sexiest Female in 2003,[6] she started a relationship with then Ajax footballer Rafael van der Vaart.

Their fame grew after their marriage on 10 June 2005 and live coverage of the wedding on SBS6, a Dutch television channel, with the broadcast gaining high ratings in the Netherlands; Sylvie took Rafael's last name, van der Vaart.

Meis and her then husband moved to Germany when he left Ajax to play for Bundesliga football club Hamburger SV.

On 17 April 2010, Meis replaced the usual Deutschland sucht den Superstar judge Nina Eichinger for the final of the 7th season, after the latter was stuck in Los Angeles following flight restrictions as a result of the 2010 eruptions of Eyjafjallajökull.

[5] Following in the footsteps of famous entertainers such as Johannes Heesters, Linda de Mol and Rudi Carell, Meis is one of the most successful Dutch personalities active in Germany.

[15] In 2010, Meis admitted to having cheated on her husband, stating that van der Vaart found out through emails that she was having an affair with a KLM airline pilot which she believed was the beginning of the end of their marriage.