Born in Saint-Leu-la-Forêt, after a classical baccalaureate degree (Latin-Greek), Oussenko entered the Institut Catholique de Paris, then at the Sorbonne for a degree in philosophy, while taking singing lessons with Paul Derenne, then with Franz Müller-Heuser [de] in Cologne and drama classes with Dominique Rozan, sociétaire of the Comédie-Française.

She worked on the repertoire with vocal coach Irène Aïtoff, with whom she gave her first recital devoted to lieder and melodies by Franz Liszt in 1978: many others followed.

Then, opting for recital and oratorio, she created many melodies by Roger Calmel , Georges Delerue, Lucie Robert-Diessel,[1] Noël Lee, Pierrette Mari, etc.

She works on an ongoing basis with pianists Françoise Tillard,[2] Noël Lee, Lucie Robert-Diessel, and conductor Dominique Fanal.

In 2013, the Quatre Mythologiques are put on music by Michel Decoust, song cycle on poems by Sylvie Oussenko (excerpts from the collection Pèlerinages).