The Symmes Mission Chapel was a historic church building in the city of Fairfield, Ohio, United States.

Shortly after the organization of the congregation, the original church building was constructed at a cost of $1,180 on land donated by Benjamin Symmes,[3] seemingly in 1843.

The sanctuary was decorated with ornamental woodwork, including bullseye designs, while much of the interior was covered with tongue and groove panelling.

By that time, it was one of very few pre-Civil War buildings remaining in Fairfield, which was quickly becoming more and more of an exurb in the Cincinnati metropolitan area.

Noting the church's place among contemporary commercial development, the surveyor observed deterioration in both interior and exterior, and by that time the building was seemingly close to collapse.