The Oxford Female Institute was affiliated with the Presbyterian Church, and its first president was John Witherspoon Scott.

His second daughter Caroline Scott, an Oxford Institute graduate, married Benjamin Harrison and became First Lady after his election as President of the United States in 1888.

Miami University took over ownership of the school in 1928 and absorbed its students.

Miami used the building, commonly known as "Ox College", as a women's residence hall for more than sixty years.

This article about a property in Butler County, Ohio on the National Register of Historic Places is a stub.