She served as national press secretary for Bernie Sanders' 2016 presidential campaign (no relation).

[4] In April 2019, Sanders joined the 2020 presidential campaign of former vice president Joe Biden as a senior advisor,[5][6] and after Biden won election, was named chief spokesperson and a senior advisor for Vice President Kamala Harris.

[10] Her mother, Terri Sanders, is the former publisher of the Omaha Star and former executive director for the Great Plains Black History Museum.

[15] Later that year, she joined CNN as an analyst and commentator,[16] and was recognized by Rolling Stone magazine[17] as one of 16 Young Americans Shaping the 2016 Election.

[5][6] In 2020, she published a memoir, No, You Shut Up,[1] relating her personal experiences of speaking up to effectively fight ideological battles.

On November 29, 2020, Sanders was named chief spokesperson and a senior advisor for Vice President Kamala Harris.