In Synapse, which is played from first-person, the player assumes the role of a special agent who must infiltrate the mind of a rogue colonel and extract intel to stop a plan that will result in mass destruction.

The game utilizes the eye-tracking functionality of the PlayStation VR2 headset, allowing players to select interactable objects through simply looking at it.

The game features three distinct skill trees, focusing on the player character's weapons, telekinetic abilities, and general resilience.

[2] David Hayter and Jennifer Hale were cast as Colonel Peter Conrad and Handler Clara Sorensen respectively.

[3] Graham Banas from Push Square liked the frentic gameplay, though he felt that the monochromatic visuals failed to create distinctive in-game environments, and noted that Synapse did not have content.