[2] Blotched upside-down catfish are small, reaching a maximum of 9.6 centimetres (3.8 in) SL.

This is reflected in the fish's pigmentation – their bellies are darker than their backs, a form of countershading.

[4] Synodontis nigriventris are mostly nocturnal, and feed on insects, crustaceans, and plant matter.

[6] By swimming upside down when it feeds,[7] it can readily catch prey at the surface from beneath.

[4] The blotched upside-down catfish is well suited to aquariums because of its small size (typically 9 or 10 cm or less) and peaceful demeanor.