Syracuse is a city in Otoe County, Nebraska, United States.

[5][6] According to the United States Census Bureau, the city has a total area of 1.27 square miles (3.29 km2), all land.

There were 903 housing units at an average density of 711.0 per square mile (274.5/km2).

36.3% of all households were made up of individuals, and 23.1% had someone living alone who was 65 years of age or older.

There were 798 housing units at an average density of 850.8 per square mile (328.5/km2).

31.0% of all households were made up of individuals, and 22.4% had someone living alone who was 65 years of age or older.