The Syracuse City School District is a public school district serving students in pre-kindergarten through twelfth grade from Syracuse, New York.

The board hires a superintendent under contract to carry out its policies.

The Syracuse Say Yes to Education and Economic Development program is a district-wide collaboration between Say Yes, Syracuse University, and the Syracuse City School District aimed at bridging the achievement gap between urban and suburban children by focusing on academic, social-emotional, health, and financial obstacles facing low-income students.

[3] The following support systems are offered through the Syracuse Say Yes to Education program: annual and regularly reviewed individual student growth plans; tutoring; identification of strengths and weaknesses through student diagnostic testing; inclusive settings, curriculum, and support for students with disabilities and English language learners; after-school and summer school programs; counseling and family engagement; research-based academic programs such as International Baccalaureate often found in suburban schools; financial aid and college selection counseling; and mentoring.

[3] The Syracuse Higher Education Compact is a partnership between private and public institutions to "collectively provide the opportunity for Say Yes graduates in the city of Syracuse to attend college with tuition, fees, and books paid for.