Syringocystadenoma papilliferum is a rare non-malignant adnexal neoplasm that develops from apocrine or eccrine sweat glands and can be identified histologically by cystic, papillary, and ductal invaginations into the dermis lined by double-layered outer cuboidal and luminal high columnar epithelium and connected to the epidermis.

[1] Lesions have a heterogeneous, non-distinctive appearance that ranges from skin-colored to pink-colored papules or plaques.

It is present at birth in approximately 50% of individuals affected, and it develops before puberty in the remaining 15%-30%.

[4] Symptoms of Syringocystadenoma papilliferum include papules, lack of hair on the scalp, blisters, subcutaneous nodules, and nevus sebaceous.

Characteristics of Syringocystadenoma papilliferum are dilated capillaries and a dense infiltration of plasma cells.