These tumors, which resemble serous acinar cells, vary in their behavior from locally aggressive to blatantly malignant.

There have been rare cases of primary tumors involving the parapharyngeal space and the sublingual gland.

Patients with acinic cell carcinomas with high grade transformation (sometimes also called dedifferentiation) have significantly worse survival.

[2] Salivary gland cancers seem on the rise in many Western Nations and their risk factors are still the challenges ahead, not being fully identified.

Fewer than 1% of malignancies beginning in the lower respiratory tract are acinic cell carcinomas.