The Syro-Malankara Catholic Eparchy of St. Ephrem of Khadki was established by Pope Francis on 23 November 2019.

It is for the Syro-Malankara Catholics of Maharashtra, Goa, Andhra Pradesh, Telangana and parts of Tamil Nadu and Karnataka.

It has its pro-cathedral see in the town of Khadki, near Pune, in western India's Maharashtra state.

The mission of the Syro-Malankara church began in 1955 with the founding of Bethany Ashram in Pune for the pastoral care of migrants.

[2] On 23 November 2019 it was elevated in the rank of eparchy[3] and become dependent from Major Archbishop, because of extension of the territorium proprium of the Syro-Malankara Catholic Church.