Systemic disease

Getting a regular eye exam may play a role in identifying the signs of some systemic diseases.

This unique feature makes the eye susceptible to a wide variety of diseases as well as provides insights into many body systems.

Almost any part of the eye can give important clues to the diagnosis of systemic diseases.

"[4] Since 500 B.C., some researchers have believed that the physical condition of the fingernails and toenails can indicate various systemic diseases.

[5] Pitting also may be caused by a variety of systemic diseases, including reactive arthritis and other connective tissue disorders, sarcoidosis, pemphigus, alopecia areata, and incontinentia pigmenti.