[1] During the barbarian invasions, many ethnic groups moved through the region, and there is archeological evidence of hundreds of graves belonging to Iazyges, Sarmatians, Gepids, Huns, and Avars.

[4] Following the Hungary's defeat by Ottoman forces at the battle of Mohács, taxes were levied from Szentes by three different powers, meaning those who were able to leave the area, fled.

The region further suffered during the Long Turkish War, with more towns going extinct, and many of Szentes' inhabitants seeking refuge by dwelling in the nearby wetlands.

In 1693, Szentes and the surrounding region was scorched and pillaged by Crimean Tatars looking for food following their failed attempt to capture Gyula.

After the Habsburgs crushed the revolution, many young men were forcibly enlisted in the Imperial Army as punishment, and the mayor was sentenced to hard labour.