Tonse Madhava Ananth Pai (30 April 1898 – 29 May 1979), was an Indian physician, educationist, banker and philanthropist, most well-known for building the university town of Manipal, India.

He was the first to start a private, self-financing medical college offering MBBS in India.

He, along with his brother Upendra Ananth Pai, also established Syndicate Bank originally in Udupi, Karnataka, which has its headquarters now in Manipal and Bangalore.

Born in 1898, Tonse Madhava Ananta Pai belonged to a lower-middle-class household of Gowd Saraswath Brahmins of Kallianpur, a village in Udupi.

Pai has also been recognized by Ripley's Believe It or Not as the person who has established the most number of educational institutions in his lifetime.