Twenty-two years later, a punk couple having sex in the bathhouse are killed and dismembered by someone, who flushes the victims' remains down a toilet before meticulously cleaning the crime scene.

Nineteen years later, Teodora, her boyfriend Vaki, and their friends Tina and Sale visit the bathhouse (where what sounds like an infant's cries and laughter frequently emanate from the plumbing) to buy drugs from a pair of dealers named Cane and Sleš.

Convinced that the drunk is the murderer, Cane impulsively shoots him to death; the man is afterward revealed to have been innocent when Sale discovers that his dropped camcorder had briefly recorded the real killer, who is wearing boots similar to Djordjevic's.

Assisting Margita are a deranged former professor named Dragi HadžiTošić (who has filled the sewers with traps for catching both people and crocodiles) and Cane, who she had abducted as a toddler and raised as her son.

Syndrome was similarly praised by Ain't It Cool News, which called it "a landmark film" and "an outstanding establishing of a potentially great author" with a directorial-style that was comparable to both Dario Argento's and Lars von Trier's.