Holmes left CNN at the end of 2011 after signing a multi-platform talent deal with BET Networks, which included the new show Don't Sleep.
Holmes moved back to his home state of Arkansas in 2000 to join CBS affiliate KTHV in Little Rock as a general assignment reporter.
In 2003, Holmes moved on to KNTV, the NBC O&O station in the San Francisco Bay Area, to become anchor of the 5 p.m. evening news.
While at KNTV, he traveled to Athens, Greece to cover the 2004 Olympics, the first Summer Games held after the September 11th attacks.
While at KNTV, he covered numerous other stories that garnered national attention, including the historic recall election of California Gov.
At CNN, Holmes reported from the scene of numerous breaking news events, including Joplin, MO, which was devastated by multiple tornadoes in May 2011, New Orleans during the Deepwater Horizon oil spill in 2010; and, Blacksburg, VA immediately after the shootings on the campus of Virginia Tech.
Holmes covered the historic first papal visit to the United States of Pope Benedict XVI in 2008, including anchoring live from the mass at Yankee Stadium.
Holmes secured some of the first stories from the survivors of the US Airways Flight 1549 that crash landed in the Hudson River in January 2009.
"[9] In August 2012, BET Networks announced that Holmes will be the host of their new original series Don't Sleep, which will premiere October 1, 2012 from 11 p.m.-11:30 p.m.
Airing Monday through Thursday, Holmes will deliver smart, biting social commentary on significant issues important to the black community.
[2] After much speculation in March 2013, BET announced they had cancelled Don't Sleep and that Holmes had left the network.
Starting on June 24, 2013, Holmes made a brief return to the Turner family of networks when he anchored coverage of the George Zimmerman trial.
[14] On December 5, 2022, Holmes and his GMA3 co-host Amy Robach were taken off the air following the public disclosure of a romantic relationship between the two.
[citation needed] He has two children from previous relationships, daughter Brianna and son Jaiden.
"[28] In October 2024, Holmes injured his Achilles tendon which caused him to drop out of the remainder of the Chicago Marathon.