1045253333ENSG00000130204ENSMUSG00000002984O96008Q9QYA2NM_001128916NM_001128917NM_006114NM_001109748NM_016871NP_006105.1NP_001103218NP_058567Mitochondrial import receptor subunit TOM40 homolog is a protein which in humans is encoded by the TOMM40 gene.

More precisely, TOMM40 is the channel-forming subunit of the translocase of the outer membrane (TOM) complex, a translocase of the outer mitochondrial membrane that is essential for protein transport into the mitochondrion.

[7] Certain alleles of this gene have been statistically associated with an increased risk of developing late-onset Alzheimer's disease.

[8][9] One study has found that TOMM40 risk alleles appear twice as often in people with Alzheimer's disease than those without it.

[10] Because TOMM40 is located on chromosome 19, and is closely adjacent to APOE,[6] another gene known to be associated with Alzheimer's, another study has suggested that the statistically significant correlation of TOMM40 with Alzheimer's is due to linkage disequilibrium.