TVOTR has released five studio albums: Desperate Youth, Blood Thirsty Babes (2004), Return to Cookie Mountain (2006), Dear Science (2008), Nine Types of Light (2011), and Seeds (2014), alongside several EPs.

The first release from TV on the Radio (initially just founding members Adebimpe and Sitek) was the self-released OK Calculator (the title being a reference to Radiohead's album OK Computer.

[5] The band's second album, Return to Cookie Mountain, leaked in early 2006 and garnered pre-release praise from Pitchfork Media[6] before its official release in July.

[8] During the US tour, TVOTR performed a few covers with Bauhaus vocalist, Peter Murphy, and Nine Inch Nails frontman, Trent Reznor.

[20] A solo album by Dave Sitek, Maximum Balloon, was released August 24, 2010, and featured a variety of guest vocals by many of his musician friends, such as Karen O, David Byrne, and both of his TVOTR vocalist bandmates.

[21] In addition, Sitek produced Holly Miranda's album The Magician's Private Library, which also featured fellow TVOTR members Jaleel Bunton and Kyp Malone.

In March 2010, Tunde Adebimpe designed a charity t-shirt for the Yellow Bird Project to raise money for Haiti Relief via Partners in Health.

"[26] In May 2013, TVOTR headlined and curated the All Tomorrow's Parties music festival, held at Pontins holiday camp in Camber Sands, England, at which they debuted the new song "Mercy".

[27] They began streaming the studio version of "Mercy" online on July 30, 2013, and released the song for sale at digital music outlets a short time later.

"[32] TV on the Radio has said that their eclectic music is due to their appreciation for diverse bands, including Bad Brains, Earth, Wind & Fire, Nancy Sinatra, Serge Gainsbourg,[33] Brian Eno,[34] and Pixies.