Ta Phraya (Thai: ตาพระยา, pronounced [tāː pʰrā.jāː]) is the northeasternmost district (amphoe) of Sa Kaeo province, eastern Thailand.

When the community grew bigger, the government created the Ta Phraya minor district (king amphoe) in 1959.

Kho Khlan Subdistrict in Ta Phraya district was the site of the Khao-I-Dang Cambodian refugee camp opened in the late 1970s during the Cambodian–Vietnamese War.

The Sankamphaeng Range mountainous area is in the northern section of this district.

The district is divided into five sub-districts (tambons), which are further subdivided into 61 villages (mubans).