The series began as a horror anthology, but soon branched out into other genres as well.

Taboo most notably serialized Alan Moore and Eddie Campbell's From Hell, Moore and Melinda Gebbie's Lost Girls, and Tim Lucas, Mike Hoffman and David Lloyd's Throat Sprockets, which became the basis of Lucas' prose novel of the same name.

It also featured work by Moebius, Chester Brown, Neil Gaiman, Dave Sim, Michael Zulli, Al Columbia, and Charles Vess.

An early version of Charles Burns coming of age body horror graphic novel, Black Hole, features in the first issue as Contagious.

Bissette's own imprint Spiderbaby Grafix & Publications published the first seven issues, as well as a "Taboo Especial" one-shot, from 1988 until 1992.