Tachosil is an equine collagen sponge coated with the human plasma-derived coagulation factors fibrinogen and thrombin.
[2][5] It is used during surgery to stop local bleeding on internal organs (hemostasis).
[2] Tachosil reacts upon contact with blood, other body fluids or saline to form a clot that glues it to the tissue surface.
[4] Tachosil may cause an allergic reaction, thrombosis (blood clots), a blockage in the intestine when used during abdominal surgeries, the formation of scar tissue and foreign body granuloma (a type of inflammatory reaction).
[1] Tachosil is indicated in adults for supportive sealing of the dura mater to prevent postoperative cerebrospinal leakage following neurological surgery.