When the Tenochtitlan and Texcoco decided to ally against Azcapotzalco, Tlacopan did not resist and for this reason is considered to be the third of the Aztec Triple Alliance.

In the name of King Charles V, Cortés assigned this important region of the capital to her as an encomienda, or grant of tribute and labor, as part of the dowry and security he arranged for her and several others of Monctezuma's children.

The 120 Tacuba households in this large encomienda were to provide regular tribute to Isabel Moctezuma in the form of different kinds of fowl, eggs, corn, tortillas, or cacao beans.

Isabel's encomienda grant was officially administered by a succession of Spanish husbands until her death in 1550, but her heirs continued to reap benefits from it for generations.

Tacuba has major problems with uncontrolled street vending and public transportation, prostitution and other crime.

The façade is mostly Baroque with the portal marked the two grooved Doric columns and topped by a frieze with vegetative design done in relief.

The interior is focused on the main altar, which is gilded and has twelve colonial era paintings of the Virgin Mary and various saints along with Salomonic columns.

Here are the remains of a Montezuma cypress, under which it is said that Hernán Cortés sat and wept after being run out of Tenochtitlan during La Noche Triste in 1520.

Next to the plaza where this tree is found, there is an old mansion whose east side has a mural called “Noche de la Victoria” (Night of the Victory) done in 2010.

Today it is the site of the Universidad del Ejército y Fuerza Aérea which still trains part of Mexico’s military.

It is considered to be generous in granting miracles and is in a glass case surrounded by toys given by the faithful to favors received.