He served in the 442nd Infantry Regiment as a language specialist during World War II and went on to attend Cannon School of Business in Honolulu.
A friend, who had been working as a movie extra, introduced him to actors Charles Laughton and Burgess Meredith, who were both art collectors.
In 1965 Sato was honored by President Lyndon Johnson at the White House Festival of Arts, alongside Georgia O'Keeffe, Jackson Pollock and other American artists.
Along with Satoru Abe, Bumpei Akaji, Edmund Chung, Tetsuo Ochikubo, Jerry T. Okimoto, and James Park, Tadashi Sato was a member of the Metcalf Chateau, a group of seven Asian-American artists with ties to Honolulu.
He is known for his abstract and semi-abstract paintings, mosaics, and murals, some, such as Submerged Rocks, inspired by the clear water of his native Hawaii.