[6] He did post-doctoral research at Harvard University and Massachusetts General Hospital where his work focused on structural studies of the Na,K-ATPase.
[11][12] He has written on a broad range of medical ethical issues,[13] including ethical prescription and use of opioids,[14] use of performance-enhancing drugs in professional athletics,[15] animal/human hybrids,[13] artificial nutrition and hydration,[13] conscience rights for health care providers and patients,[13] in vitro fertilization,[13] palliative and hospice care,[13] and physician-assisted suicide.
[13] Since 2001, he has given several hundred presentations[16] and invited lectures,[17] and continues to speak widely on contemporary bioethical themes throughout the U.S., Canada, and Europe.
On October 7, 2012, Pacholczyk wrote a piece in the Wall Street Journal titled "Please Step Back From the Assisted-Suicide Ledge"[20] in which he notes, "If physician-assisted suicide really represents a good choice, we need to ask: Why should only physicians be able to participate?"
In December 2001, Pacholczyk testified before the Massachusetts Senate that "embryonic human life is inviolable and deserving of unconditional respect.