The Taipei Economic and Cultural Office in Spain; (Chinese: 駐西班牙台北代表處; pinyin: Zhù Xībānyá Dàibiǎo Chù) (Spanish: Oficina Económica y Cultural de Taipei en España) represents the interests of Taiwan in Spain in the absence of formal diplomatic relations, functioning as a de facto embassy.

Its counterpart in Taiwan is the Spanish Chamber of Commerce in Taipei.

[1] Previously, Spain recognised Taiwan as the Republic of China, which was represented by an embassy in Madrid.

[4] There were close relations between the governments of Francisco Franco and Chiang Kai-shek, both of which were anti-communist.

[5] However, diplomatic relations were severed in 1973 when Spain recognised the People's Republic of China.