She first established herself as a rapper under the tutelage of Eazy-E. After releasing her debut album, Power of a Woman (1990) on Ruthless Records, she formed the rap metal band Manhole (later Tura Satana).

On October 30, 2015, cult director John Waters commented on Tairrie B's rap career and legacy in his interview with Iggy Pop on BBC Radio 6 just before playing "Ruthless Bitch" saying, "..she was very much a part of the story, she was the first white girl rapper I remember.

"[8] On October 20, 2020, Tairrie B released a new album, Feminenergy, with 12 songs that she described as "socially conscious, politically reflective, hardcore tracks of hip hop, rock & resistance.

"[9] The album addresses racism, social injustice, sexism, and contains tributes to the passing of civil rights icon John Lewis and United States Supreme Court Justice Ruth Bader Ginsburg.

The album features Mick Murphy (My Ruin), Paul Catten (Dead Sheeran, Barrabus, Murder One, Lazarus Blackstar, Medulla Nocte), and Spokane DJ, GrandMixer GMS (KFOX Nightbeat & Global Frequency).