His well-known roles include heroes such as Cloud Strife in Compilation of Final Fantasy VII, Suzaku Kururugi in Code Geass, X in Mega Man X, Arataka Reigen in Mob Psycho 100, Giyu Tomioka in Demon Slayer: Kimetsu no Yaiba, and Burton in Ninjala, as well as villains such as Maximilien Robespierre in Le Chevalier D'Eon, Hiltz in Zoids: Guardian Force, Sasori in Naruto Shippūden, Rohan Kishibe in JoJo's Bizarre Adventure: Diamond is Unbreakable, and Suguru Geto in Jujutsu Kaisen.

Sakurai and Joy were accused of copyright infringement, as Eternity was based on Kōki Mitani's stage play Tokyo Sunshine Boys' Trap.

[7] In 2013, after a year of discussions with the record company, Sakurai announced on his radio show that he would be singing the character song for Shirokuma Cafe.

[8] On October 25, 2016, Sakurai stepped on the red carpet at the 27th Tokyo International Film Festival as John Paul in Genocidal Organ with Yuichi Nakamura as Clavis Shepherd.

Sakurai lists people like Ryūsei Nakao, Chō, Ryōtarō Okiayu, Tomokazu Seki, and Minami Takayama as his favorite and respected voice actors,[3] and he had a close relationship with Keiji Fujiwara in his private life.

In addition to the eyecatching illustrations in Canvas 2: Niji Iro no Sketch, he was also a member of the key drawing staff for the final episode of Code Geass: Lelouch of the Rebellion R2,[10] and was credited as a logotype designer for the second season of Active Raid.