[1] The expressway is an important route connecting the greater Osaka area with Takamatsu, the capital of Kagawa Prefecture.

The first section of the Takamatsu Expressway to open was between Zentsuji and Mishima-Kawanoe interchanges on 16 December 1987.

The final section of the expressway (9.1 km between Takamatsu-Chūō and Takamatsu-Nishi Interchanges) was opened on 30 March 2003.

The 16.2 kilometres (10.1 mi) long Takamatsu-higashi Road was incorporated into the Takamatsu Expressway on 21 November 2017.

[2] Due to open the expressway from Takamatsu towards Matsuyama, kilometer markers between Naruto Toll Gate and Takamatsu-Nishi Interchange show the distance from Naruto Toll Gate plus 100 (the marker at Naruto Toll Gate is 100.0 while the marker at Takamatsu-Nishi Interchange is 165.4).