Takatsu Ward is located in eastern Kanagawa Prefecture, in the north-center portion of the city of Kawasaki, bordering on Tokyo.

Mizonokuchi, Futago, Seta, Suwa, Kitamigata, Shimonoge, Hisamoto, Sakado, Kuji, Unane, Shimo-Sakunobe, Kami-Sakunobe, Mukaigaoka, Suenaga, Kajigaya, Shinsaku, Chitose, Chitose-Shin-cho, Shibokuchi, Shibokuchi-Fujimi-dai, Hisasue, Kanigaya, Akutsu, and Nogawa.

Under the Nara period Ritsuryō system, it became part of Tachibana District Musashi Province.

After the Meiji Restoration, the area was divided into eight villages within Tachibana District in the new Kanagawa Prefecture on April 1, 1889.

Takatsu Ward is largely a regional commercial center and bedroom community for central Kawasaki and Tokyo.