Trained by Todd Pletcher Charming won on her debut at Keeneland, but sustained a serious injury at Monmouth Park in July and was retired from racing.
Ridden by Corey Lanerie she took the lead soon after the start and drew away in the closing stages to win "very easily"[6] by two and a half lengths from Conquest Archangel.
Four weeks later, the filly was moved up in class and distance for the Grade III Schuylerville Stakes over six furlongs at Saratoga Race Course and finished second to the odds-on favorite Fashion Alert.
Take Charge Brandi was then sent to California to contest the thirty-first running of the Breeders' Cup Juvenile Fillies over one and one sixteenth of a mile at Santa Anita Park on November 1.
The Chandelier Stakes winner Angela Renee started as the favorite ahead of Conquest Eclipse, Puca, Cristina's Journey and Top Decile.
Ridden for the first time by Paco Lopez, the favorite tracked the early leader Vivian Da Bling before gaining the advantage on the final turn.
"[11] Take Charge Brandi made her three-year-old debut with a close victory over Sarah Sis in Oaklawn Park's Martha Washington Stakes.
Ridden by Luis Saez, she led the field into the straight before tiring in the closing stages and was eased down to finish last of the ten runners behind Cavorting.
[14] On November 3, Take Charge Brandi was sold for $6 million at the Keeneland breeding stock sale to Hill 'n' Dale Farm.