The song relates to Psalm 55:22: Cast thy burden upon the LORD, and he shall sustain thee: he shall never suffer the righteous to be moved.and to Christ's words in the Gospel of Matthew at 11:28-30: Come unto me, all ye that labour and are heavy laden, and I will give you rest.

Take my yoke upon you, and learn of me; for I am meek and lowly in heart: and ye shall find rest unto your souls.

It also relates to the Gospel of Matthew at 6:26: Behold the fowls of the air: for they sow not, neither do they reap, nor gather into barns; yet your heavenly Father feedeth them.

On December 2, 1927, the song was recorded in gospel blues style by Washington Phillips (vocals and zither).

On June 30, 1928, it was recorded in gospel style by the Pace Jubilee Singers (chorus, singing in close harmony) with Hattie Parker (vocal soloist) and piano accompaniment.