Takhar holds notoriety as the location where Mujahideen Commander Ahmad Shah Massoud was assassinated on 9 September 2001 by suspected al-Qaeda agents.

Following the September 11 attacks, commonly known as 9/11, and amidst the United States' intervention, General Mohamad Daud and General Shajahan Noori, both widely recognized figures, played instrumental roles in leading the Afghanistan government forces to reclaim control of the northeastern province from the Taliban.

[8][9] In April 2012, the water supply at the Rostaq district's school for girls was poisoned by unknown insurgents, sickening at least 140 Afghan schoolgirls and teachers ranging in age from 14 to 30, causing them to be hospitalized and some to partially lose consciousness, though there were no deaths as a result of the incident.

In response, Mohibullah Noori emerged as a prominent figure, leading the second resistance to support security forces and prevent the Taliban from taking control of Taluqan city.

On 26 October, the 7.5 Mw Hindu Kush earthquake shook northern Afghanistan with a maximum Mercalli intensity of VIII (Severe).

Gold is being washed in Takhar River, and about 2 kg are being transported to the specific weekly markets in the city of Taloqan.

While the mines offer economic opportunities in the region, the availability of iodized salt considerably reduces the prevalence of health problems related to iodine deficiency.