She has performed with artists including Chick Corea, Jeff Beck, Prince, Incubus, Eric Clapton, Herbie Hancock, Toto, and Mick Jagger.

[5] Love Remains has been highly praised by the press and was featured in Rolling Stone, Relix, Paste, Billboard, and Forbes.

Rolling Stone described her vocal debut as having "ten dense, riff-heavy tracks with brazen, introspective lyrics—prove her songwriting abilities.

Wilkenfeld has recorded on projects with Ringo Starr, Brian Wilson, Toto, Todd Rundgren, Macy Gray, Dr. John, Trevor Rabin, Jackson Browne, Joe Walsh, Rod Stewart, John Mayer, Sting, Ben Harper, David Gilmour, Pharrell, Buddy Guy, Billy Gibbons, Lee Ritenour, Hiram Bullock, Susan Tedeschi, and Hans Zimmer, and Playing for Change with Carlos Santana.

She credits Oteil Burbridge and Derek Trucks with encouraging her to join them at the Beacon Theatre,[10] her first time on a large stage.

In 2006, months after performing as a guest with the Allman Brothers Band, Wilkenfeld recorded her debut album, Transformation, in only two days.

Wilkenfeld composed, produced, arranged and played bass on seven songs with Wayne Krantz, Geoffrey Keezer, saxophonist Seamus Blake and Keith Carlock.

By November 2007, Wilkenfeld rejoined Beck and the other band members for a week-long residency at Ronnie Scott's Jazz Club in London.

Beck selected the venue to record a new DVD and CD, with guests including Clapton, Joss Stone, and Imogen Heap.

On the same trip, Wilkenfeld joined Herbie Hancock, Wayne Shorter, singer Corinne Bailey Rae, and drummer Colaiuta on a session filmed for the A&E series, Live from Abbey Road.

At the end of the tour, Krantz, Carlock, and John Beasley backed Wilkenfeld during her headlining set for Bass Player LIVE!

She appeared at Warren Haynes's 20th Annual Christmas Jam while reuniting and performing with the Allman Brothers and guesting with Gov't Mule, Ivan Neville, and Robben Ford.

The process culminated in Welcome 2 America - Prince's 2021 album and first posthumous release with previously unreleased music featuring Wilkenfeld on bass on 10 of the 12 tracks, recorded in 2010.

Weeks later the group toured the United States, beginning with Beck's induction into the Rock and Roll Hall of Fame.

In October 2009, Wilkenfeld reunited with Jeff Beck at Madison Square Garden for the Rock and Roll Hall of Fame's 25th Anniversary two-night concert.

The set included Buddy Guy on "Let Me Love You Baby", Sting singing "People Get Ready", and Billy Gibbons on "Foxey Lady".

The 25th Anniversary Rock and Roll Hall of Fame Concerts DVD, which also included "Big Block", "A Day in the Life", and "Freeway Jam", was released in 2010.

In 2010, Wilkenfeld appeared in the Baked Potato's 40th anniversary show at the Ford Amphitheater with Steve Lukather's band; she accompanied Hancock across the U.S., Canada, and Europe promoting a new release on which she had played.

In September 2011, Wilkenfeld accompanied Steven Tyler and Jeff Beck at the iHeartRadio Music Festival at the MGM Grand Garden Arena.

In January and February 2023, she played five shows with Incubus while their bassist Ben Kenney recovered from brain surgery.