Talagante Province (Spanish: Provincia de Talagante, Spanish pronunciation: [talaˈɣante]) is one of six provinces of the Santiago Metropolitan Region in central Chile.

The capital is the city of Talagante, located approximately 35 km (22 mi) southwest of the national capital of Santiago.

The most northeastern part of the province is included in the Santiago conurbation.

As a province, Talagante is a second-level administrative division of Chile, governed by a provincial delegate who is appointed by the president.

The province comprises five communes (Spanish: comunas), each governed by a municipality consisting of an alcalde and municipal council: The province spans an area of 582.3 square kilometres (582 km2), the smallest in the Santiago Metropolitan Region.