[1] Construction of the street started around 1840, after the sale of Tyrone House and was further accelerated by the opening of the Dublin railway in 1846.

An iron railway bridge, constructed in around 1890 by A. Handyside & Co. of Leeds, runs over the east end of the street.

A plaque of remembrance marks the spot and is the focus of an infrequent commemoration attended by large numbers of Tipperary people on the morning of the All-Ireland Hurling Final in years when the Tipperary team participate,[4] thus underlining the close association of the Gaelic Athletic Association with Irish nationalism.

In 1943, Dublin Corporation passed a motion urging a change of name subject to the support of the majority of ratepayers on Talbot Street.

[5] One of the street's most famous residents was Alfie Byrne, ten times Lord Mayor of Dublin.

78 Talbot Street (on the corner of Moland Place) is the site of the former Welsh Church or Capel Betel, designed by the architect William Murray (1789–1844),[11] it is now a protected structure.

[13] Established in 1838 (first service on Sunday 4th of November 1838), its ethos was Calvinistic Methodism, and was affiliated to the Anglesea circuit.

John Lewis was the church's minister from 1894 to 1934, he tutored the politician Ernest Blythe, who attended services to study Welsh (as did other members of the Gaelic League).

The former church has subsequently been a shoe shop (Griffiths), a snooker hall, an amusement arcade,[15] and an Internet cafe.

An eleven-bay three-storey building with a basement, Talbot House was built in 1842 as a Teacher Training School for women.

Construction began in 1971 after Irish Life bought a set of Warehouses on Talbot Street in order to redevelop the land.

The mall is part of the Irish Life Centre, which is a conglomerate of retail and office space, and apartments, with underground parking, and has a large frontage on Talbot Street.