A youth graduate from Bahia, where he arrived in 2009, Talisca made his professional debut against Corinthians on 7 July 2013, and scored his first goal in the next match against São Paulo.

[9] On 31 October, he scored his eighth and fourth consecutive goal in Primeira Liga, in a home win against Rio Ave (1–0), keeping the top scorer lead.

[15] On 13 September, on his return to the Estádio da Luz in a Champions League group game, he scored an added-time free kick to ensure a 1–1 draw.

[18] On 8 June 2018, Talisca was loaned out to Chinese Super League side Guangzhou Evergrande Taobao for a half year, with the transfer costing €5.8 million.

[19][20] He made his debut for Guangzhou Evergrande as a starter and scored a hat-trick, including a direct free kick, to help his team win 4–0 over Guizhou Hengfeng in the league on 18 July.

[22] On 26 October 2018, Benfica announced that Talisca had moved permanently to the Chinese club for a transfer fee of €19.2 million.

[31] On 11 November 2014, Talisca was called up by Dunga to the Brazil national team to replace Lucas Moura in the international fixtures against Turkey and Austria.