All TalkShoe hosts are required to register on the website in order to participate, however guests can listen to a show via the web client without registration.

A podcast may cover any subject matter the host desires, but may not include forbidden content such as pornographic or racist material.

TalkShoe's software allows hosts to start or stop the recording of their podcast, and to mute or unmute the text and voice chat ability of guests in the show.

Early talkcasts were by local Pittsburgh personalities, including radio talkshow hosts who simulcast via TalkShoe as another method of broadcasting their show and taking call-ins.

On January 27, 2007, former Iowa governor Tom Vilsack discussed his presidential policy plans on TalkShoe, appearing on the Regular Guys Show hosted by Kurt Hurner.

Vilsack came back onto TalkShoe on the Kurt Hurner Show on August 12, 2008, this time as a representative of the Barack Obama for President campaign.