Tallula is an unincorporated community in Issaquena County, Mississippi, United States.

Tallula is a name derived from the Choctaw language purported to mean either (sources vary) "bell" or "to break off".

[2] The settlement was originally located on a spot along the Mississippi River called Tallula Bend.

[4] In 1856 the sheriff of Issaquena County offered a $250 reward for the recapture of a "negro stealer" named John Guydon who "broke jail" at Tallula.

"[3] Charles C. Diggs, Sr., the first African-American Democrat elected to the Michigan Senate, was born in Tallula.